Povezanost nivoa citokina u serumu i dijetalnog inflamatornog indeksa kod oboljelih od kolorektalnog karcinoma i njihov značaj u kolorektalnom karcinomu/
Connection between serum cytokine levels and dietary inflamatory index in patients with colorectal cancer and their significance in colorektal cancer
Povezanost nivoa citokina u serumu i dijetalnog inflamatornog indeksa kod oboljelih od kolorektalnog karcinoma i njihov značaj u kolorektalnom karcinomu/
Connection between serum cytokine levels and dietary inflamatory index in patients with colorectal cancer and their significance in colorektal cancer
Датотеке
Датум
2024
Аутори
Lana Sarajlić
Наслов журнала
Журнал ISSN
Наслов волумена
Издавач
Univerzitet u Istočnom Sarajevu, Medicinski fakultet Foča
University of East Sarajevo, Faculty of Medicine Foca
University of East Sarajevo, Faculty of Medicine Foca
Апстракт
Prema podacima iz internacionalne baze za posmatranje karcinoma u 2018. godini ukupno u svijetu diagnostikovano je 18 miliona novih slučajeva svih karcinoma i zabilježeno je 9,6 miliona smrtnih ishoda. Od svih karcinoma dijagnostikovanih kod oba pola, KRK bio je treći najčešći karcinom (nakon karcinoma dojke i pluća) i drugi vodeći uzrok smrtnog ishoda od karcinoma (nakon karcinoma pluća). Dalje, ako se posmatra prema polu, kod muškaraca, KRK je nakon karcinoma pluća i prostate treći najčešće dijagnostikovani karcinom od svih karcinoma kod muškaraca). Kod ţena, KRK je nakon karcinoma dojke drugi najčeše dijagnostikovani karcinom od svih karcinoma kod ţena.
Ciljevi istraživanja su bili da se utvrdi koncentracija pro-inflamatornih citokina i anti-inflamatornih citokina u serumu oboljelih od KRK i uporedi sa koncentracijom kod zdravih ispitanika i unutar grupe oboljelih u zavisnosti od lokalizacije, histološkog gradusa tumora i stadijuma bolesti te da se utvrde vrijednosti DII skora kod oboljelih od KRK i uporede sa vrijednostima kod zdravih ispitanika i unutar grupe oboljelih u zavisnosti od lokalizacije, histološkog gradusa tumora i stadijuma bolesti. Cilj je bio i utvrditi povezanost koncentracije pro-inflamatornih citokina i anti-inflamatornih citokina sa vrijednošću DII skora kod oboljelih od KRK.
Istraţivanje je sprovedeno po dizajnu eksplorativne prospektivne studije slučajeva i kontrola u Univerzitetskoj bolnici Foča tokom 2018. i 2019. godine. Grupu slučajeva činilo je 110 pacijenata kod kojih se tokom sprovođenja studije postavila patohistološka dijagnoza kolorektalnog karcinoma. Grupu kontrola činilo je 110 pacijenata bez dijagnoze KRK, a koji su u isto vrijeme liječeni u Univerzitetskoj bolnici Foča.
Rezultati su pokazali da su pacijenti sa KRK imali ĉešću pojavu KRK u porodici, rjeđu fizičku aktivnost, češće bili pušači, češće konzumirali mesne prerađevine i imali više vrijednosti CRP, AST i tumorskih makera CEA i CA 19-9 u serumu u odnosu na kontrolne ispitanike, značajno više serumske koncentracije pro-inflamatornih citokina IL-6 i IL-17A, i značajno niže koncentracije anti-inflamatornog citokina IL-10 u odnosu na pacijente sa lijevo lokalizovanim tumorom. Pacijenti sa većim TNM stadijumom imali su značajno više koncentracije pro-inflamatornih citokina IL-6 i IL-17A, a značajno niže koncentracije anti-inflamatornog citokina IL-10. Pacijenti sa slabo diferentovanim tumorom stadijumom imali su značajno više koncentracije pro-inflamatrnog citokina IL-6, a značajno niže koncentracije anti-inflamatornog citokina IL-10 u odnosu na pacijente sa umjereno i dobro diferentovanim tumorom. Pacijenti sa KRK imali su značajno više prosječne vrijednosti ukupnog DII skora u odnosu na kontrolne ispitanike, tj. njihova ishrana bila je više pro-inflamatorna. Ukupni DII skor bio je značajno veći tj. više proinflamatoran kod pacijenata sa KRK desnog kolona, kod pacijenata sa IV u odnosu na I/II, i u odnosu na III stadijum bolesti. Pacijenti sa slabo diferentovanim tumorom imali su više vrijednosti DII skora u odnosu na pacijente sa dobro diferentovanim tumorom. Pacijenti koji su imali više vrijednosti DII skora, koje ukazuju na pro-inflamatornu ishranu, imali su istovremeno i značajno više koncentracije serumskog pro-inflamatornog citokina IL-6. Pacijenti koji su imali niže vrijednosti DII skora, koje ukazuju na anti-inflamatornu ishranu imali su istovremeno i značajno više koncentracije anti-inflamatornog citokina IL-10.
According to data from the International Cancer Monitoring Database, in 2018, a total of 18 million new cases of all cancers were diagnosed worldwide and 9.6 million deaths were recorded. Of all cancers diagnosed in both sexes, CRC was the third most common cancer (after breast and lung cancer) and the second leading cause of cancer death. Furthermore, if we look at gender, in men, CRC is the third most frequently diagnosed cancer of all cancers in men, after lung and prostate cancer). In women, CRC is the second most frequently diagnosed cancer of all cancers in women, after breast cancer. The goals of the research were to determine the concentration of pro-inflammatory cytokines and anti-inflammatory cytokines in the serum of patients with CRC and compare it with the concentration in healthy subjects and within the group of patients depending on the localization, histological grade of the tumor and the stage of the disease, and to determine the DII values score in patients with CRC and compared with values in healthy subjects and within the group of patients depending on localization, histological grade of the tumor and stage of the disease. The goal was also to determine the association of the concentration of pro-inflammatory cytokines and anti-inflammatory cytokines with the value of the DII score in CRC patients. The research was conducted according to the design of an exploratory prospective study of cases and controls at the Foĉa University Hospital during 2018 and 2019. The group of cases consisted of 110 patients in whom a pathohistological diagnosis of colorectal cancer was made during the study. The control group consisted of 110 patients without a diagnosis of CRC. The results showed that patients with CRC had a more frequent occurrence of CRC in the family, less physical activity, were smokers more often, consumed meat products more often and had higher values of CRP, AST and CEA and CA 19-9 in the serum, significantly higher serum concentrations of the pro-inflammatory cytokines IL-6 and IL-17A, significantly lower concentrations of the anti-inflammatory cytokine IL-10 compared to patients with a left localized tumor. Patients with a higher TNM stage had significantly higher concentrations of the pro-inflammatory cytokines, and significantly lower concentrations of the anti-inflammatory cytokine. Patients with a poorly differentiated tumor stage had significantly higher concentrations of the pro-inflammatory cytokine IL-6, and significantly lower concentrations of the anti-inflammatory cytokine IL-10. Patients with CRC had a significantly higher average value of the total DII score. The total DII score was significantly higher in patients with CRC of the right colon, in patients with IV compared to I/II and III stage of the disease. Patients with a poorly differentiated tumor had higher values of the DII score compared to patients with a well-differentiated tumor. Patients who had higher values of the DII score had a significantly higher concentration of the serum pro-inflammatory cytokine IL-6. Patients who had lower values of the DII score had simultaneously and significantly higher concentrations of the anti-inflammatory cytokine IL-10.
According to data from the International Cancer Monitoring Database, in 2018, a total of 18 million new cases of all cancers were diagnosed worldwide and 9.6 million deaths were recorded. Of all cancers diagnosed in both sexes, CRC was the third most common cancer (after breast and lung cancer) and the second leading cause of cancer death. Furthermore, if we look at gender, in men, CRC is the third most frequently diagnosed cancer of all cancers in men, after lung and prostate cancer). In women, CRC is the second most frequently diagnosed cancer of all cancers in women, after breast cancer. The goals of the research were to determine the concentration of pro-inflammatory cytokines and anti-inflammatory cytokines in the serum of patients with CRC and compare it with the concentration in healthy subjects and within the group of patients depending on the localization, histological grade of the tumor and the stage of the disease, and to determine the DII values score in patients with CRC and compared with values in healthy subjects and within the group of patients depending on localization, histological grade of the tumor and stage of the disease. The goal was also to determine the association of the concentration of pro-inflammatory cytokines and anti-inflammatory cytokines with the value of the DII score in CRC patients. The research was conducted according to the design of an exploratory prospective study of cases and controls at the Foĉa University Hospital during 2018 and 2019. The group of cases consisted of 110 patients in whom a pathohistological diagnosis of colorectal cancer was made during the study. The control group consisted of 110 patients without a diagnosis of CRC. The results showed that patients with CRC had a more frequent occurrence of CRC in the family, less physical activity, were smokers more often, consumed meat products more often and had higher values of CRP, AST and CEA and CA 19-9 in the serum, significantly higher serum concentrations of the pro-inflammatory cytokines IL-6 and IL-17A, significantly lower concentrations of the anti-inflammatory cytokine IL-10 compared to patients with a left localized tumor. Patients with a higher TNM stage had significantly higher concentrations of the pro-inflammatory cytokines, and significantly lower concentrations of the anti-inflammatory cytokine. Patients with a poorly differentiated tumor stage had significantly higher concentrations of the pro-inflammatory cytokine IL-6, and significantly lower concentrations of the anti-inflammatory cytokine IL-10. Patients with CRC had a significantly higher average value of the total DII score. The total DII score was significantly higher in patients with CRC of the right colon, in patients with IV compared to I/II and III stage of the disease. Patients with a poorly differentiated tumor had higher values of the DII score compared to patients with a well-differentiated tumor. Patients who had higher values of the DII score had a significantly higher concentration of the serum pro-inflammatory cytokine IL-6. Patients who had lower values of the DII score had simultaneously and significantly higher concentrations of the anti-inflammatory cytokine IL-10.